Since 2003 the Framingham Heart Study has included endothelial function measurements with EndoPAT. All three study cohorts (the original study population, the Offspring, and the 3rd generation cohort) have been tested with EndoPAT, totaling over 5,000 subjects. A crosssectional analysis of 1,957 3rd generation subjects was published in Circulation (May 2008) by Hamburg et al. The study demonstrated a significant inverse relation between EndoScore and multiple CV risk factors, including: male sex, body mass index, total/HDL cholesterol, diabetes, smoking, and lipid-lowering treatment. |
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