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JOURNAL OF THE AMERICAN COLLEGE OF CARDIOLOGY |
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EndoPAT Correlates With Assessment Of Coronary Endothelial Function |
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EndoPAT provides high degrees of sensitivity and specificity when compared to the assessment of coronary artery endothelial function. Coronary endothelial function is quantified by measuring arterial diameter change and blood flow in response to graded intra-coronary infusion of acetylcholine during angiography. In a study performed by Bonetti et al at the Mayo Clinic, a group of 94 subjects underwent angiographic assessment of coronary endothelial function and subsequent EndoPAT tests. The results of this comparative study served as the basis for the FDA clearance of the EndoPAT in the detection of coronary endothelial dysfunction. An EndoPAT index cutoff value of 1.67 provides a sensitivity of 82% and a specificity of 77% and AUC 0.82 for diagnosing coronary endothelial function. |
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Noninvasive Identification of Patients with Early Coronary Atherosclerosis by Assessment of Digital Reactive Hyperemia. |
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Bonetti PO, Pumper GM, Higano ST, Holmes DR Jr., Kuvin JT, Lerman A. JACC 2004; 44: 2137-2141 |
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