Background: Assessed the effects of therapeutic lifestyle changes (TLSC) on endothelial function (EF) measured by EndoPAT in 150 patients with abdominal obesity and moderate CV risk, randomized to either conventional medical care group (CG) or one-year TLSC group (IG). EF, IMT (U.S. assessment of atherosclerosis of the carotid artery) and lifestyle (LS) assessed before and after intervention. The authors wanted to see whether adherence to life style modification in patients with CVD risk and obesity will improve their clinical status beyond conventional medical care. Results: EndoScore index improved in IG and worsened in CG. Global CV risk reduced in IG (P = 0.017). Improvement in ≥ two LS components was associated with EndoScore increase (P = 0.051). EndoScore increase determined less IMT progression (P = 0.053). Conclusions: Good adherence to TLSC reduces global CV risk and improves EndoPAT index. Moreover, it clearly shows how well the EndoPAT can be used as an important follow up tool for identifying the response to various cardiovascular treatment lifestyle changes. |
