PAT® Technology

PAT® technology is a non-invasive window to the cardiovascular system and autonomic nervous system. Peripheral Arterial Tone (PAT®) signal is a proprietary technology used for non-invasively measuring arterial tone changes in peripheral arterial beds.

The PAT® signal is measured from the fingertip by recording finger arterial pulsatile volume changes.
Based on PAT® technology, the non-invasive EndoPAT system comprises a measurement apparatus that supports a pair of modified plethysmographic bio-sensors. The unique feature of the PAT® bio-sensors is that they impart a uniform sub-diastolic pressure field to the distal two thirds of the fingers including their tips. Applying the pressure in this way is extremely important as it:

  • Prevents distal venous blood pooling, that can induce a veno-arteriolar vasoconstriction reflex
  • Unloads arterial wall tension which generates a greater dynamic range of the measured PAT® signal
  • Fixates the PAT® bio-sensor to the finger, which reduces movement artifacts


Endothelial Function

Atherosclerosis Timeline

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EndoPAT assesses digital flow mediated dilation during reactive hyperemia using measurements from both arms – occluded side and control side.
EndoPAT provides an index of endothelial function in two forms: RHI and LnRHI

RHI (Reactive Hyperemia Index) is the post-to-pre occlusion PAT® signal ratio in the occluded side, normalized to the control side and further corrected for baseline vascular tone.
Normal: RHI > 1.67
Abnormal: RHI ≤ 1.67

LnRHI is a similar index after natural log transformation with a matched cutoff:
Normal: LnRHI > 0.51
Abnormal: LnRHI ≤ 0.51

Natural log is a monotonic transformation therefore it does not change the dichotomous diagnosis for any individual test.
LnRHI provides a better double sided distribution than RHI that is closer to normal distribution. It offers better separation between disease states.

Risk Score Calculator

The EndoPAT ™ Risk Score Calculator provides the 3 most commonly used cardiovascular risk assessment methods:

  • Framingham Risk Score: Estimates 10 year risk of Coronary Heart Disease, MI or cardiac death (Adults treatment panel III, JAMA 2001). Applies to subjects without known heart disease or diabetes. Utilities different models for men and women using the following predictors: age, total cholesterol, HDL, systolic blood pressure, treatment for hypertension and smoking.
  • Score: The European estimate of a 10 year risk of fatal CVD (EHJ, 2003). Charts are divided to low risk regions (Belgium, France, Greece, Italy, Luxemburg, Spain and Portugal) and high risk regions (all other European countries) using the following predictors: gender, age, total cholesterol, systolic blood pressure and smoking.
  • Reynolds Risk Score: Provides 10 years’ risk of MI, stroke, revascularization or cardiac death (JAMA 2007, Circ 2008). Reynolds risk score uses the following predictors: gender, age, total cholesterol, HDL, systolic blood pressure, hsCRP and parent MI before age 60.

Additional tests provided (not for clinical use in USA)

Augmentation Index (AI)

Atherosclerosis Timeline

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Measures arterial stiffness is calculated via pulse waveform analysis of the PAT® signal and is considered an independent risk factor for CVD not necessarily correlated to endothelial function.

AI is calculated from PAT® pulses recorded at the base-line period.
The result is further normalized to heart rate of 75bpm (AI@75).

Lower AI values (including negative results) reflect better arterial elasticity.
The AI result is provided relative to gender matched, non-selective populations.

Heart rate variability (HRV)

Atherosclerosis Timeline

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A measure of heart beat-to-beat variability in either time or frequency domain.
HRV reflects the status of the autonomic nervous system (ANS) and is associated with the balance between sympathetic and parasympathetic activities that may reflect various pathological conditions.

The HRV is calculated from the baseline period, based on the ESC and North American Society of Pacing Electrophysiology task force standards.
Results are available in various time and frequency domain formats.

Itamar Medical Standard

Itamar Medical products share the common concept of uniquely designed, single-use PAT® finger probes, optimally tailored to measure the PAT® signal with application-specific algorithms. The data acquired is automatically processed, analyzed, and presented to the physician by proprietary software. This standard provides for user-independent, highly-reliable, and reproducible medical devices, facilitating clinicians’ decision making process and researchers’ work in a user-friendly environment necessitating very little training.
Itamar Medical’s PAT® based devices strategically position the company to meet the diagnosis and consulting needs of busy medical centers and private practices in the 21st century.

Intellectual Property

The PAT® Signal and methodology has a strong intellectual property position. Eight patents have been issued in the use to date, and over forty worldwide, with numerous applications currently pending. The first allowed US patent claim was very comprehensive and includes the following statement:
“Monitoring changes in peripheral arterial tone and determining that a change in the physiological condition of the patient has occurred”

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Key Features
PAT™ (Peripheral Arterial Tone) Technology
Risk for Atherosclerosis
Endothelial Dysfunction
Women’s Heart
Wellbeing & arterial health
Physicians’ Case Studies