What if you could identify high risk patients at the earliest stage
of their cardiovascular disease - would you treat them differently?
The EndoPAT – the only FDA-cleared test for the non-invasive assessment
of Endothelial Dysfunction (arterial health); clinically proven by leading cardiologists
through prestigious peer-reviewed studies as a valuable tool in cardiovascular
risk stratification beyond commonly used tests.
The EndoPAT™ Solution
  • The only FDA-Cleared device indicated for the diagnosis of Endothelial Dysfunction. Accurate & Reproducible
The EndoPAT™ Test
  • Non-invasive diagnosis and measurement of early endothelial damage In-office EndoPAT™ test.
Results in 15 just minutes
  • Easy to Use. Fully automated, both operator and interpreter independent. Results in 15 just minutes.
PAT™ Signal

PAT™ Signal

PAT™ technology is a non-invasive window to the cardiovascular system and autonomic nervous system. Peripheral Arterial Tone (PAT™) signal is a proprietary technology used for non-invasively measuring arterial tone changes in peripheral arterial beds.

The PAT™ signal is measured from the fingertip by recording finger arterial pulsatile volume changes.
Based on PAT™ technology, the non-invasive EndoPAT system comprises a measurement apparatus that supports a pair of modified plethysmographic
bio-sensors.

The unique feature of the PAT™ bio-sensors is that they impart a uniform sub-diastolic pressure field to the distal two-thirds of the fingers including their tips.

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Endothelial Dysfunction

Endothelial Dysfunction

For more than a decade endothelial dysfunction has been recognized by the medical community as the critical junction between risk factors and clinical disease. It is the earliest detectable stage of cardiovascular disease. Furthermore, it is treatable, and unlike the atherosclerotic plaque that it causes, it is even reversible.

The Endothelium is the inner lining of all blood vessels, considered a “super organ” that regulates key natural biological processes that ensures homeostasis, amongst them inflammation, oxidative stress
and auto-immune disease.

The endothelium is the thin layer of flat, smooth cells that line the inner walls of the 62,000 miles of
blood vessels in the body.

As major negative lifestyle factors begin to increase, oxidative stress damages the endothelial tissue throughout the body by stiffening the veins and arteries, leading to a host of medical concerns, including erectile dysfunction, kidney disease, peripheral vascular disease, heart attack, and stroke.

Numerous studies positioned Endothelial Dysfunction as the “ultimate risk of risk factors” and is the earliest clinical detectable stage of cardiovascular disease.

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Clinical Uses and Implications

Clinical Uses and Implications

Atherosclerosis, the build-up of plaques within the walls of the arteries, is caused when the endothelial cells that line the thousands of miles of blood vessels become dysfunctional. We also know that endothelial dysfunction is caused by the same heart risks that initially damage the endothelium.

Based on new clinical findings, many leading cardiac researchers now believe that endothelial dysfunction, considered as “the ultimate risk of the risk factors”, is a disease unto itself and that this disease is what causes damage to the vessels of the heart, not atherosclerosis. Furthermore, this dysfunction is triggered by an inflammatory response to the damaged endothelium. Atherosclerosis, and the subsequent plaques and arterial blockages and heart attacks that it causes, are manifestations of this endothelial dysfunction.

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Non-invasive

Validated vs. invasive gold standard
(intracoronary infusion of acetylcholine)

Reliable & Reproducible

Immediate, automatically calculated test results,
interpreter independent

Easy to Use

Short (15-minute), convenient (performed at the fingertip),
office-based test, operator independent